Longevity · prescription telehealth

Your own growth hormone, prompted. Not replaced.

compounded sermorelin · nightly injection · prescription only

For growth-hormone support as the years add up. Compounded sermorelin is a small nightly injection that prompts your pituitary to release your own growth hormone in its natural pulses — the hormone your body makes less of with age. 1 2 People ask for it for sleep, recovery and lean mass; the studies behind those hopes are small and mixed, and this page tells you what they found. A licensed clinician decides whether it is appropriate for you, chooses your starting dose, and moves it only on how you respond.

Start the intake See plans on this page

About eight minutes. A licensed clinician reviews every answer — and can say no.

Mechanism

your pituitary releases it — sermorelin only asks

Dosing

chosen for you, moved only on your response

Terms

first month and every renewal shown before you pay

About Sermorelin

What sermorelin does, and what the evidence really says.

What it does

Sermorelin is a growth-hormone-releasing-hormone analogue: a copy of the signal your hypothalamus sends to your pituitary. 1 2 It binds the same receptors and prompts the pituitary to release your own growth hormone in brief pulses — the signal itself lasts minutes — and your body's feedback controls stay in the loop. 2 3 That is the difference between prompting growth hormone and taking it.

How it's taken

A small subcutaneous injection with a fine insulin-type needle, at bedtime and on an emptier stomach: growth hormone's largest natural pulse follows the onset of deep sleep, and food and glucose blunt the response. 3 12 Your clinician sets the schedule and chooses the dose for you; nothing changes without notice.

What to expect

Honestly: the adult evidence is small, short and mostly in older adults, and there is no large modern trial. 3 4 In those small studies, growth-hormone-releasing-hormone analogues raised growth-hormone and IGF-1 levels; in one placebo-controlled study of several months, lean body mass increased in the men taking part, and sleep quality did not change. 5 6 Injection-site reactions are the most common effect. 2 Results vary. Compounded sermorelin is not FDA-approved.

The routine. Your clinician writes the dose and the schedule.

A difference in mechanism, not a promise of results.

Every study behind this page is listed under Sources at the bottom, small ones called small. Nothing here is a promise of results — it is what the studies found, at the scale they found it.

How the dose moves

Calibrated to you, in the open.

Sermorelin is not a one-size script. Your clinician chooses a starting dose for you, watches how you respond, and moves it only for a reason — with notice before anything changes.

A starting dose, chosen for you

Your clinician sets the first dose from your intake — health history, sleep, what you already take, what you are trying to change. The starting point is deliberately conservative; the point is to learn how you respond.

The first weeks: learning your response

Injection-site reactions, if they happen, usually show early and usually settle. 2 In the studies, IGF-1 — the marker growth hormone drives — rose within the first weeks; what you notice yourself varies, and your clinician wants to hear it either way. 6

Check-in: hold, adjust or stop

On what you report — sleep, recovery, side effects — your clinician holds the dose, adjusts it, or stops treatment. A dose change is theirs to make, never automatic, and you hear about it before your next billing.

Why it stalls

The same dose for everyone, renewed automatically, with no one reading what you report back.

What calibrated care does

Your dose is chosen for you and moved only on your response, by a clinician, with notice before your billing changes and the option to hold.

If one of those routes is genuinely working for you, keep it. The consult exists to say no as readily as yes.

Prompted, not replaced. That is the whole idea.

A principle of the house

How care works

Medicine, measured.

Results are personal, so treatment shouldn't be one-size. Here is the whole process, plainly.

An intake worth reading

About eight minutes of real questions — health history, medications, goals. It is the basis of every decision that follows.

A clinician decides

A licensed U.S. clinician reviews your answers and decides whether sermorelin is appropriate for you. Sometimes the answer is no — you'll hear it straight.

Prepared and delivered

If prescribed, your medication is prepared by a state-licensed U.S. compounding pharmacy — named on your prescription label — and shipped in discreet, unmarked packaging.

Calibrated over time

Your care doesn't end at delivery. Dosing is adjusted to your response, with notice before anything changes — and the option to hold where clinically appropriate.

Plans & pricing

Straight terms, before you pay.

Every plan includes the clinician evaluation, preparation, shipping and follow-up. The first month is an introductory price; the standing monthly price and the quarterly price are on the cards, in the same view, before you pay.

Monthly supply First month

Sermorelin Injection

$149 / first month

then $199/month from month 2 · cancel anytime

Compounded sermorelin, a small nightly subcutaneous injection
Prompts your own growth-hormone release — it is not growth hormone
Starting dose chosen for you, moved only on your response
Prepared for your prescription by a state-licensed U.S. compounding pharmacy, shipped discreetly
Charged only after a clinician prescribes; cancel any time before your next billing
Compounded medications are not FDA-approved

3-month supply

Sermorelin Injection

$529 / every 3 months

renews at $529 every 3 months · cancel anytime

Compounded sermorelin, a small nightly subcutaneous injection
Prompts your own growth-hormone release — it is not growth hormone
Starting dose chosen for you, moved only on your response
Prepared for your prescription by a state-licensed U.S. compounding pharmacy, shipped discreetly
Charged only after a clinician prescribes; cancel any time before your next billing
Compounded medications are not FDA-approved

What it costs, entirely: the price on the card is the whole price. The evaluation, the prescription if one is written, preparation, discreet shipping and ongoing clinician follow-up are all inside it, and there is no separate fee for any of them. Your card is pre-authorised at checkout and charged only after a licensed clinician issues your prescription; if the answer is no, you are not charged. Monthly plans renew each month at the standing price shown on the card — month four costs what month two costs — and the quarterly plan renews every three months at its own price. Cancel any time before your next billing date from your account or by emailing the care team; cancelling stops future charges. If your clinician changes your dose in a way that changes your price, you hear about it before your next billing, with the option to hold where clinically appropriate. Compounded sermorelin is prepared by a state-licensed U.S. compounding pharmacy and, like all compounded drugs, is not FDA-approved.

Eligibility

See if it's appropriate. That's the consult.

Sermorelin is prescribed to adults when a licensed clinician decides it is appropriate for their history and goals. The intake asks about the things that change that decision — and the answer is sometimes no.

You may qualify if

You are an adult aged 18 or over
You want provider-guided growth-hormone support as you get older, with honest expectations
You can take a small subcutaneous injection at bedtime, on a schedule
You are not on growth hormone or another growth-hormone secretagogue — or you tell us that you are
A clinician confirms it fits your health history

May not be suitable if

You are pregnant, planning a pregnancy, or breastfeeding
You have active cancer or are under oncology care — growth hormone and IGF-1 are growth signals, so this is a hard line
You have an untreated thyroid disorder, which blunts the response, or diabetes that is not well controlled
You have had an allergic reaction to sermorelin or to anything it is prepared with
You have a significant uncontrolled heart, kidney or liver condition

This is not an exhaustive list — your clinician reviews your full medical history before any prescribing decision, and can decline.

Safety & honesty

What it can do to you, and what nobody knows yet.

Sermorelin's safety record comes mostly from its years as an approved diagnostic and children's medicine, and from small adult studies. 2 3 Long-term use in adults for this purpose has not been studied at scale, and long-term animal studies for cancer risk were never performed. 2 Here is what is known.

What the original trials recorded

Injection-site reactions — pain, swelling or redness where you inject — the most common effect, in about one patient in six in the original trials, usually mild and usually easing 2
Less common, each in under one patient in a hundred — headache, flushing, dizziness, difficulty swallowing, hyperactivity, drowsiness, hives 2
Blood sugar — growth-hormone pathways can change insulin sensitivity in either direction; the studies are mixed, so your clinician watches rather than assumes 5 6 18

Stop and tell your clinician

Hives, swelling of the face or throat, or trouble breathing — the signs of an allergic reaction
Chest tightness, or a swallowing difficulty that does not pass
A persistent or worsening headache, a change in vision, or swelling of the hands and feet
Any new lump, or a change in an existing one

Not prescribed if

A known allergy to sermorelin or to anything it is prepared with — the only contraindication on the original label 2
Pregnancy, a planned pregnancy, or breastfeeding 2
Active cancer or current oncology care 3 19
Untreated thyroid disease, or poorly controlled diabetes — until they are managed — both change how your body responds to it 2

Medicines that need care

Tell your clinician about everything you take. Steroid tablets can blunt the response; thyroid medicines and untreated thyroid disease change it; insulin and other diabetes medicines need care because the growth-hormone pathway acts on blood sugar. 2 Growth hormone itself, or another peptide acting on the same pathway, must never be layered on top without your clinician knowing.

Monitoring

Your clinician follows your response through what you report — sleep, recovery, side effects — and may ask for blood work where a result would change a decision: IGF-1, the marker growth hormone drives, with the aim of an age-appropriate normal range rather than a maximum; thyroid function, because an untreated thyroid blunts the response; blood sugar. 2 3 Blood work is not a condition of starting; it is a tool your clinician uses when it matters.

What it is for

Sermorelin is prescribed here for adults as provider-guided support. It is not a treatment for diagnosed growth-hormone deficiency, it is not prescribed to children through this service, it is not a weight-loss treatment, and it will not build muscle by itself.

If you stop

If you stop, the extra signal stops: sermorelin itself is cleared within minutes of each dose, so your growth-hormone pattern returns to its own baseline and there is no withdrawal to manage. 2 Cancel before your next billing date and no further charges are made.

Compounded sermorelin is not FDA-approved. It is prepared for your prescription by a state-licensed U.S. compounding pharmacy, and the FDA does not review compounded drugs for safety, effectiveness or quality before they are sold. 17

Results vary. No outcome is guaranteed — your clinician will discuss what is realistic for you.

The effects and precautions above are drawn from the original prescribing information for sermorelin and from the adult studies listed under Sources. 2 3 5 6 7

What happens next

From intake to first injection, plainly.

Nothing here should be a mystery, so here is the whole path — including what turns up at your door.

The intake

About eight minutes: health history, medications, sleep, what you already take, and your state. Your card is pre-authorised at checkout, not charged.

The decision

A licensed clinician reviews your answers, typically within a day, and decides. If sermorelin is not appropriate for you, you hear that straight — and you are not charged.

Preparation

If prescribed, your card is charged and a state-licensed U.S. compounding pharmacy prepares sermorelin for your prescription. That pharmacy is named on your label.

Delivery

Shipped to you in discreet, unmarked packaging with the pharmacy's instructions for storing, preparing and injecting it. Keep it refrigerated as the label directs.

Calibration

Your clinician follows how you respond and adjusts, holds or stops — with notice before any change that affects your billing.

What arrives

Medication

Compounded sermorelin in a small vial, prepared for your prescription. The pharmacy that prepared it is named on the label.

Supplies

The pharmacy's written instructions for storing, preparing and injecting it, with the injection supplies it provides for your prescription.

Paperwork

Your prescription label and the pharmacy's information sheet. The care team is one message away for anything that is unclear.

What ships, and the supplies in the box, follow your prescription and the pharmacy that prepares it; the photograph shows the kind of thing to expect, not your exact order.

Certified

LegitScript-certified healthcare merchant

Private

HIPAA-compliant platform · discreet, unmarked packaging

Clinician-led

licensed U.S. providers review every case

Your pharmacy

prepared by a state-licensed U.S. compounding pharmacy, named on your prescription label

Questions, answered plainly

Questions about sermorelin

Is sermorelin the same as growth hormone?

No. Growth hormone — somatropin — supplies the hormone itself. Sermorelin is a growth-hormone-releasing-hormone analogue: it prompts your pituitary to release your own growth hormone in its natural pulses, with your body's feedback controls still in charge. 1 2 3 It is prescribed here only when a clinician decides it is appropriate for you.

Is this legal, and is it the same as the "research" vials sold online?

Sermorelin here is prescribed by a licensed clinician and prepared for your prescription by a state-licensed U.S. compounding pharmacy — that is what makes it a medicine rather than a chemical. "Research use only" peptides are sold without a prescription, without a clinician, and without anyone accountable for what is in the vial; their labels say "not for human use" because they are not. Compounded sermorelin is not FDA-approved, and we say so plainly. 17

Wasn't sermorelin an approved medicine once?

Yes — as Geref, for diagnostic pituitary testing and for growth-hormone deficiency in children, never for adults. The manufacturer discontinued it in 2008 and the approvals were withdrawn in 2009 at its request; in 2013 the FDA determined they had not been withdrawn for reasons of safety or effectiveness — a commercial finding, not a safety endorsement. 15 16 What is prescribed today is compounded, and compounded drugs are not FDA-approved. 17

What does the evidence actually show?

Less than the marketing around peptides suggests, and we would rather tell you. In small studies of older adults, growth-hormone-releasing-hormone analogues raised growth-hormone and IGF-1 levels. 5 6 In one placebo-controlled study of several months, lean body mass increased in the men taking part, sleep quality did not change, and no other body-composition measure moved. 6 11 The studies that measured strength found little. 3 Given at bedtime to young men in a sleep laboratory, the hormone deepened slow-wave sleep; that effect is smaller in older adults and is still being studied. 9 10 There is no large modern trial of sermorelin in adults. Your clinician sets expectations with you rather than promising outcomes.

When do people notice anything?

The studies measured hormones, body composition and sleep in a laboratory, not how people felt week by week. IGF-1 rose within the first weeks; lean-mass change, where it came, took months. 6 What you notice is individual and, where it comes, gradual rather than dramatic: some people report sleeping or recovering better, some report little. Results vary, and your clinician reviews honestly whether it is doing anything for you.

What happens when my dose changes?

Only your clinician changes it, on your response, and you hear about it before your next billing — with the option to hold at your current dose where clinically appropriate. If a change affects your price, the new price is shown before you are charged.

How much medication do I actually get?

The vial strength and the number of nights it covers are written on your prescription and on your label, and your clinician's message spells them out before anything ships. If your clinician changes your dose, the supply and the price change together — and you hear about it first. Nothing about your supply is decided by a marketing page.

Do I need blood work?

Not to start. Your clinician may ask for labs — IGF-1, thyroid function, blood sugar — where a result would change a decision about your dose or about whether to continue. The aim with IGF-1 is an age-appropriate normal range, not a maximum. 3

Does it hurt, and can I do it myself?

It is a small injection with a fine insulin-type needle into the fat under the skin of the stomach or thigh, at bedtime — a few seconds. Most people manage it themselves after the first one; the pharmacy's instructions walk you through it, and the care team is a message away. Soreness where you inject is the most common effect and usually eases. 2

Do I really have to take it on an empty stomach at bedtime?

Emptier, not empty. Food and glucose blunt the growth-hormone response to sermorelin, and the body's own largest pulse follows the onset of deep sleep — so the dose goes at bedtime, a while after your last meal, rather than after a late dinner. 3 12 Eat earlier; do not skip eating. Your clinician sets a timing that fits your evening.

Is it different for women?

In the placebo-controlled study, the lean-mass increase reached significance in the men; in the women, skin thickness increased and the hormonal response was smaller in those taking oral oestrogen. 6 In sleep-laboratory studies the hormone's effect on sleep differs by sex, and one study found it disturbed sleep in healthy young women. 20 None of that rules sermorelin out for women — it means your clinician weighs it, and watches your response rather than assuming it.

Who prepares it, and what arrives?

A state-licensed U.S. compounding pharmacy prepares sermorelin for your prescription; it is named on your label. It arrives in discreet, unmarked packaging with the pharmacy's instructions. It is not FDA-approved — compounded medications are not reviewed by the FDA for safety or effectiveness. 17

What if it isn't working, or I want to stop?

Say so. Your clinician can adjust the dose, or agree that it is not for you. Stopping is simple: cancel before your next billing date from your account or by emailing the care team, and no further charges are made. There is no withdrawal to manage. 2

Can I take it alongside NAD+ or testosterone therapy?

Often, but only with your clinician knowing everything you take — the intake asks specifically. Growth hormone itself, or another peptide acting on the same pathway, should not be layered on top without a clinician's direction.

How does the telemedicine process work?

You complete an online intake, a licensed provider reviews your case, and if appropriate your treatment plan is prescribed and delivered directly to your door.

Do I need to visit a doctor in person?

No. All consultations, prescriptions, and follow-ups are handled 100% online through our secure telehealth platform.

Are the doctors licensed?

Yes. Every provider in our network is licensed and experienced in evaluating patients through compliant telemedicine workflows.

Is my personal information secure?

Your information is protected through secure systems and privacy-first processes designed to support HIPAA-aligned care delivery.

How is my medication delivered?

Approved medications are shipped discreetly to your home, with updates and follow-up support handled online for convenience.

Sources

What this page is based on.

20 sources showhide

The studies and documents behind every factual line above. Small studies are called small; a review is called a review.

Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs, 1999. PMID 18031173. pubmed.ncbi.nlm.nih.gov/18031173/
Geref (sermorelin acetate for injection) prescribing information, EMD Serono, revised 2001 — the original approved product: mechanism, adverse reactions, precautions and interactions. FDA application records NDA 019863 and NDA 020443. accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019863
Hersch EC, Merriam GR. Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus? Clinical Interventions in Aging, 2008 (a review). PMID 18488883. pubmed.ncbi.nlm.nih.gov/18488883/
Merriam GR, Schwartz RS, Vitiello MV. Growth hormone-releasing hormone and growth hormone secretagogues in normal aging. Endocrine, 2003 (a review). PMID 14610297. pubmed.ncbi.nlm.nih.gov/14610297/
Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone-releasing hormone-(1-29) twice daily reverses the decreased GH and IGF-I levels in old men. Journal of Clinical Endocrinology and Metabolism, 1992 (ten men). PMID 1379256. pubmed.ncbi.nlm.nih.gov/1379256/
Khorram O, Laughlin GA, Yen SSC. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. Journal of Clinical Endocrinology and Metabolism, 1997 (nineteen adults, placebo-controlled, sixteen weeks). PMID 9141536. pubmed.ncbi.nlm.nih.gov/9141536/
Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism, 1997 (eleven men, six weeks). PMID 9005976. pubmed.ncbi.nlm.nih.gov/9005976/
Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA, 2000. PMID 10938176. pubmed.ncbi.nlm.nih.gov/10938176/
Kerkhofs M, Van Cauter E, Van Onderbergen A, Caufriez A, Thorner MO, Copinschi G. Sleep-promoting effects of growth hormone-releasing hormone in normal men. American Journal of Physiology, 1993 (young men, sleep laboratory). PMID 8476038. pubmed.ncbi.nlm.nih.gov/8476038/
Guldner J, Schier T, Friess E, Colla M, Holsboer F, Steiger A. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiology of Aging, 1997. PMID 9390775. pubmed.ncbi.nlm.nih.gov/9390775/
Vitiello MV, Schwartz RS, Moe KE, Mazzoni G, Merriam GR. Treating age-related changes in somatotrophic hormones, sleep, and cognition. Dialogues in Clinical Neuroscience, 2001. PMID 22034239. pubmed.ncbi.nlm.nih.gov/22034239/
Masuda A, Shibasaki T, Nakahara M, et al. The effect of glucose on growth hormone (GH)-releasing hormone-mediated GH secretion in man. Journal of Clinical Endocrinology and Metabolism, 1985. PMID 3919046. pubmed.ncbi.nlm.nih.gov/3919046/
Ghigo E, Procopio M, Boffano GM, et al. Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. Metabolism, 1992. PMID 1588839. pubmed.ncbi.nlm.nih.gov/1588839/
United States Code, Title 21, section 333(e): prohibited distribution of human growth hormone (somatrem, somatropin, or an analogue of either). law.cornell.edu/uscode/text/21/333
U.S. Food and Drug Administration. Determination that Geref (sermorelin acetate) injection was not withdrawn from sale for reasons of safety or effectiveness. Federal Register, 4 March 2013. federalregister.gov/documents/2013/03/04/2013-04827/determination-that-geref-sermorelin-acetate-injection-05-milligrams-basevial-and-10-milligrams
U.S. Food and Drug Administration. Withdrawal of approval of 92 new drug applications and 49 abbreviated new drug applications (including NDA 19-863 and NDA 20-443, Geref). Federal Register, 19 May 2009. federalregister.gov/documents/2009/05/19/E9-11628/novartis-pharmaceuticals-corp-et-al-withdrawal-of-approval-of-92-new-drug-applications-and-49
U.S. Food and Drug Administration. Compounding and the FDA: questions and answers — compounded drugs are not FDA-approved and are not reviewed for safety, effectiveness or quality before marketing. fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers
Sigalos JT, Pastuszak AW. The safety and efficacy of growth hormone secretagogues. Sexual Medicine Reviews, 2018 (a review). PMID 28400207. pubmed.ncbi.nlm.nih.gov/28400207/
Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. The Lancet, 2004 (an association in observational studies, cited for caution only). PMID 15110491. pubmed.ncbi.nlm.nih.gov/15110491/
Mathias S, Held K, Ising M, Weikel JC, Yassouridis A, Steiger A. Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women. Psychoneuroendocrinology, 2007. PMID 17850984. pubmed.ncbi.nlm.nih.gov/17850984/

The right level. The right dose. For you.

Start the intake — a licensed clinician will take it from there.

Start the intake

Eligibility screening and a prescription are required for prescription treatments. Individual results vary and no specific outcome is guaranteed. A licensed clinician determines whether treatment is appropriate — treatment is not guaranteed.

Compounded sermorelin is prepared by a state-licensed U.S. compounding pharmacy, which is named on your prescription label. Compounded drugs are not FDA-approved.