Safety & honesty
What to expect, what to watch for, and what we won't claim.
NAD+ and its precursors have been through controlled trials in people, mostly by mouth, and were well tolerated. 4 The injectable form has far less controlled data. Here is what is known.
Common, usually early, usually easing
- Injection-site soreness — redness, or a small bruise where the needle went in; rotating sites helps
- Flushing or warmth — a brief rush of warmth in the face or chest shortly after a dose
- Nausea — usually mild and short-lived — tell your clinician if it isn't
- Headache or tiredness — reported by some people in the first weeks 8
Stop and tell your clinician
- Severe chills, shaking, vomiting or fever after a dose — these have been reported to the FDA after NAD+ injections and can signal a contaminated or unsuitable product — stop and contact your care team 5 7
- Chest tightness, a racing heart, or feeling faint — reported mainly with fast infusions; not expected from a small dose under the skin, but never something to ignore 8
- Swelling of the face or lips, hives, or trouble breathing — treat as an emergency and call 911
Not prescribed if
- You are pregnant, planning a pregnancy, or breastfeeding — NAD+ has not been studied in pregnancy 8
- You have cancer or are under oncology care — NAD+ fuels cell metabolism, and its effect on an existing tumour is not established 8
- You use methamphetamine, cocaine or heroin
Medicines that need care
List every medicine and supplement you take in the intake — including NAD+ from anywhere else, and NMN or NR supplements — so your clinician can set a starting dose that accounts for them.
Monitoring
No lab test is required to start. Your clinician follows your response through the check-ins you send; if something in your history warrants labs, they will say so.
What it is for
Compounded NAD+ is prescribed here for adults who want support with energy, recovery and healthy aging, when a clinician decides it is appropriate. It is not prescribed here to treat any disease, and it is not an anti-aging cure.
If you stop
Cancel your plan and stop taking it — there is nothing to taper. If the reason is that it isn't doing anything, tell your clinician; that is useful information, not a complaint.
Compounded NAD+ is not FDA-approved. Compounded medications are prepared for an individual prescription by a state-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. NAD+ is listed by the FDA among bulk substances nominated for compounding and currently under evaluation. 6
Results vary. No outcome is guaranteed — your clinician will discuss what is realistic for you, and "not much" is a possible honest answer.