Safety & honesty
Side effects and cautions, in plain words.
Most men tolerate enclomiphene well. Here is what shows up, what to watch for, and what your clinician keeps an eye on.
Common, usually early, usually easing
- Headache
- Mood changes or irritability
- Hot flushes
- Acne or oilier skin
- Nausea
- A shift in libido, in either direction
Stop and tell your clinician
- Any change in vision — blurring, spots, sensitivity to light
- Breast tenderness or swelling
- Leg pain or swelling, chest pain or sudden shortness of breath — seek urgent care
Not prescribed if
- Primary hypogonadism — the testes can't respond to the signal, so enclomiphene can't help
- A history of prostate, breast or testicular cancer
- Liver disease, or a history of blood clots
- Untreated thyroid or adrenal conditions, or a pituitary tumour
- A previous reaction to clomiphene or enclomiphene
Medicines that need care
Tell your clinician about every medication and supplement you take, including anything hormonal.
Monitoring
Enclomiphene raises estradiol alongside testosterone, and hemoglobin and PSA move with the testosterone too. That is what follow-up labs are for, and why your clinician sets the strength rather than you. 2
What it is for
It only works when the testes can answer the signal. If your LH is already high, more signal won't help — your clinician reads that at baseline. 1
If you stop
Stop the tablet and your signals return to where they were within weeks; there is no suppressed system to recover. Your levels fall back too — the benefit doesn't outlast the treatment. 2
Compounded enclomiphene is not FDA-approved. Compounded medications are not reviewed by the FDA for safety, effectiveness or quality before they are prescribed.
Results vary. No outcome is guaranteed — your clinician will discuss what's realistic for you.